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Tobi - Tobramycin Inhalation Solution

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Updated August 11, 2008

Photo © Gold Standard

Tobi is supplied in foil pouches containing individual-dose plastic vials.

Photo © Gold Standard

Brand:

Generic:

A generic version of inhaled tobramycin is not available.

What Tobi Is:

Tobi is an inhaled version of the antibiotic tobramycin that was created specifically for the treatment of Pseudomonas aeruginosa in people with cystic fibrosis. Tobi reduces the amount of bacteria in the lungs, which can improve lung function and prevent long hospital stays.

Who Tobi is For:

People over 6 years old with cystic fibrosis who have P. aeruginosa in their lungs.

Who Shouldn't Take Tobi:

  • People who are allergic to tobramycin or other antibiotics in the same family (aminoglycocides).
  • People with severely decreased lung function (FEV1 <25%)

How to Take Tobi:

Tobi is inhaled into the lungs using a machine called a nebulizer. It is usually taken every 12 hours. To prevent developing resistance, Tobi should be taken in cycles of 28 days on the medication followed by 28 days off.

How to Store Tobi:

Tobi should be stored in the refrigerator whenever possible. If refrigeration is not available, Tobi can be stored in a dark place at room temperature up to 77 degrees. Tobi should never be exposed to extreme heat or intense light. If the solution contains particles or appears cloudy, it should be discarded.

Side Effects:

Some common side effects of Tobi include:

  • Sore throat
  • Headache
  • Unpleasant taste in the mouth
  • Hoarseness or change in voice

Safety Warnings:

Some people who take Tobi have reported hearing loss, which may be a permanent if it occurs. Tell your doctor immediately if you have:

  • Dizziness
  • Ringing in the ears
  • Reduced hearing

Tobi can also cause bronchospasm, a condition that restricts the ability to breathe. Tell your doctor immediately if you have:

  • Increased coughing
  • Wheezing
  • Shortness of breath

Before taking Tobi, tell your doctor if you:

  • Are allergic to Tobi or other aminoglycocide antibitotics, such as streptomycin, amikacin, kanamycin, neomycin, or gentamicin.
  • Are pregnant, or planning to become pregnant
  • Are breastfeeding
  • Have kidney or liver disease

Financial Assistance:

A 28-day supply of Tobi costs about $4,500, but it is covered by most insurance plans. If you do not have insurance, or your insurance does not cover Tobi, Novartis has an assistance program that may be able to help if you meet the criteria.

Source:
Novartis Pharmaceuticals Corporation. Tobi Prescribing Information.December 2007.

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